GABAergic Synchronization in Epilepsy

GABAergic Dysfunction in Autism and Epilepsy

Impaired mesial synchronization in temporal lobe epilepsy.

OBJECTIVE Temporal lobe epilepsy is commonly associated with synchronous, hyper-synchronous and des-synchronous activity. The aim of the present work is to explore synchronization activity in both mesial areas in temporal lobe epileptic patients during the interictal state. METHODS Using a cluster technique, we analyzed 17 temporal lobe epilepsy patients' records of foramen ovale electrodes a...

GABAergic Synapse Dysfunction and Repair in Temporal Lobe Epilepsy

Severe medial temporal lobe epilepsy (mTLE) is often associated with pharmacoresistant seizures, impaired memory and mood disorders. In the hippocampus, GABAergic inhibitory interneuron dysfunction and other neural circuit abnormalities contribute to hyperexcitability, but the mechanisms are still not well understood. Experimental approaches aimed at correcting deficits in hippocampal circuits ...

Synchronization of GABAergic Inputs to CA3 Pyramidal Cells Precedes

25 Here we address how dynamics of glutamatergic and GABAergic synaptic input to CA3 26 pyramidal cells contribute to spontaneous emergence and evolution of recurrent seizure-like 27 events (SLEs) in juvenile (P10-13) rat hippocampal slices bathed in low-[Mg] artificial 28 cerebrospinal fluid. In field potential recordings from CA3 pyramidal layer a short epoch of 29 high frequency oscillation ...

Synchronization and desynchronization in epilepsy: controversies and hypotheses

Epilepsy has been historically seen as a functional brain disorder associated with excessive synchronization of large neuronal populations leading to a hypersynchronous state. Recent evidence showed that epileptiform phenomena, particularly seizures, result from complex interactions between neuronal networks characterized by heterogeneity of neuronal firing and dynamical evolution of synchroniz...